3-Indolyl Furanoids as Inhibitors of Matrix Metalloproteinase-9 for Prevention of Gastric Ulcer and Other Inflammatory Diseases

1. The invention involves the development of new 3-indolyl furanoids for the treatment of gastric ulcer and other inflammatory diseases.
2. All the studied new molecules are feasible to synthesize in large scales with good yields from easily available starting materials. Therefore commercialization of this invention can be cost effective.
3. Better activity of 3-indolyl furanoids also opens the scope for the development of translational medicine in the field of drug discovery.
4. This invention is the perfect combination of synthetic chemistry and advanced biology to represent chemical biology for the prevention of gastric ulcer and other inflammatory diseases.

The invention relates to 3-indolyl furanoid compounds which act as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. The promising feature of this invention is the IC₅₀ value of 50 µM of one of the 3-indolyl furanoids.

This invention is the perfect combination of synthetic chemistry and advanced biology to represent chemical biology for the prevention of gastric ulcer and other inflammatory diseases.