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 Technology Profile

Title:

4-Hydroxyisoleucine (4-HIL) Enriched Fenugreek Extract for Management of Polycystic Ovary Syndrome (PCOS)

Value Proposition:
  • First-in-class phytopharmaceutical for Polycystic Ovary Syndrome (PCOS), addressing both metabolic (insulin resistance) and reproductive dysfunction (ovulation, follicular health).
  • Synergistic multi-component composition (4-HIL, Trigonelline, Pinitol, Raffinose) offering superior efficacy compared to single-molecule or conventional therapies.
  • Simple, scalable, and cost-effective production of 4-HIL enriched fraction and >95% pure 4-HIL without chromatography or ion-exchange resins.
  • Preclinical data demonstrates improved ovulation rate, reduced cystic follicles, and enhanced ovarian health
Summary Application:
  • Novel phytopharmaceutical from Trigonella foenum-graecum enriched in 4-Hydroxyisoleucine (4-HIL), Trigonelline, Pinitol, and Raffinose for managing PCOS.
  • Dual therapeutic benefit: improves insulin sensitivity and restores ovarian function.
  • Scalable and cost-effective production process without complex purification steps.
  • Offers a promising plant-based alternative to existing therapies for PCOS-related infertility and metabolic issues.
Advantages:
  • Safe, plant-derived formulation with known dietary acceptability.
  • Synergistic action of multiple components enhances therapeutic efficacy.
  • Effective management of both metabolic and reproductive symptoms of PCOS.
  • Cost-effective and industrially scalable production.
  • Reduced side-effect potential compared to conventional synthetic drugs.
Tech. Readiness Level:
CSIR-Central Drug Research Institute
CSIR-Central Drug Research Institute[CSIR-CDRI]
:  director[at]cdri[dot]res[dot]in
:91-522-2772450
:https://www.cdri.res.in
Industrial Applications: Formulations [Drugs and Pharmaceuticals]
Patent Application(s): IN202011002962