Patent Profile
| Patent No: | US11344858 [USA] | Application No: | US16837070 |
| Title: | Micro-electrolysis reactor for ultra fast, oxidant free, C-C coupling reaction and synthesis of daclatasvir thereof | ||
| Issue Date: | 31-05-2022 | File Date: | 01-04-2020 |
| Inventor(s): | Ajay Kumar Singh; Srihari Pabbaraja; Subhash Ghosh; Mahajan Bhushan; Taufiqueahmed Mujawar | ||
| IPC Classification: | B01J19/00, B01J19/02, C07D403/14, C25B3/29, C25B11/00, C25B11/02, C25B11/04 | ||
| Abstract: | The present invention relates to compounds of formula (1), its solvates and pharmaceutically acceptable salts having antifungal activity and its pharmaceutical composition comprising an effective amount of compound of formula (1) wherein R is substituted alkyl, alkenyl, aryl, heteroaryl, 2-thienyl, 3-thienyl, halothienyl, haloalkyl, halophenyl, or pyrrolyl; and R1 and R2, each independent of the other, are hydrogen, halogen, or alkoxy. The invention also relates to a process for the preparation of said compounds by contacting the intermediate alcohol, prepared from 1,2-O-isopropylideneglyceraldehyde and substituted phenylacetates, with acid chlorides under appropriate conditions to obtain some of the preferred compounds of the invention. | ||
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