New Invention Profile
| Publication No: | BR112017013623 [Brazil] | Application No: | BR 11 2017 0136236 |
| Title: | A DNA VACCINE FORMULATION IN CATIONIC LIPOSOME VEHICLE USEFUL FOR MAXIMIZING VACCINE POTENCY FOR LEISHMANIASIS | ||
| Publication Date: | 22-06-2017 | File Date: | 22-06-2017 |
| Inventor(s): | Nahid Ali, Amrita Das | ||
| IPC Classification: | A61K39/008, A61K39/39 | ||
| Abstract: | The present invention discloses DNA vaccination with plasmid encoding the cysteine protease C (cpc) gene of Leishmania donovani to induce effective protection against visceral leishmaniasis (VL). The DNA vaccine entrapped in the cationic liposomes comprises of a plasmid vector pVAX1 encoding L. donovani cpc gene operably linked to transcriptional regulatory sequences. The invention relates to efficacy of liposomal formulation containing the bilayer-associated adjuvant MPLA, encapsulating the DNA construct pVAX1-cpc, against lethal L. donovani infection model in BALB/c mice. This formulation of liposomal DNA vaccine is highly effective in inducing robust cell-mediated immune response against leishmanial parasites upon intramuscular administration. |
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Industrial Applications
Biotechnology [Biological Science]
Plasma [Physics]