Patent Profile
| Patent No: | IN394792 [India] | Application No: | 3864DEL2014 |
| Title: | A DNA VACCINE FORMULATION IN CATIONIC LIPOSOME VEHICLE USEFUL FOR MAXIMIZING VACCINE POTENCY FOR LEISHMANIASIS | ||
| Issue Date: | 23-12-2014 | File Date: | 23-12-2014 |
| Inventor(s): | Nahid Ali, Amrita Das | ||
| IPC Classification: | A23J3/10 | ||
| Abstract: | The present invention discloses DNA vaccination with plasmid encoding the cysteine protease C (cpc) gene of Leishmania donovani to induce effective protection against visceral leishmaniasis (VL). The DNA vaccine entrapped in the cationic liposomes comprises of a plasmid vector pVAXl encoding L. donovani cpc gene operably linked to transcriptional regulatory sequences. The invention relates to efficacy of liposomal formulation containing the bilayer-associate,d adjuvant MPLA, encapsulating the DNA construct pVAX1-cpc, against lethal L. donovani infection model in BALBIc mice. This formulation of liposomal DNA vaccine is highly effective in inducing robust cell-mediated immune response against leishmania1 parasites upon intramuscular administration. |
||
CSIR-Indian Institute of Chemical Biology[CSIR-IICB]
: director[at]iicb[dot]res[dot]in
:91-33-24730492
:https://iicb.res.in/
: director[at]iicb[dot]res[dot]in
:91-33-24730492
:https://iicb.res.in/
Industrial Applications
Bio techniques [Analytical Techniques]
Microbial [Biological Science]