New Invention Profile
| Publication No: | IN202311006898 [India] | Application No: | IN202311006898 |
| Title: | A COMPOSITION FOR TREATING PARKINSON'S DISEASE | ||
| Publication Date: | 06-12-2024 | File Date: | 02-06-2023 |
| Inventor(s): | DEEPAK KUMAR; JOY CHAKRABORTY; PRIYANKA YATHAM; CHAYAN BANERJEE; SHREYA SEN SARMA | ||
| IPC Classification: | A61K 31/37, A61K 47/14, A61K 47/44, A61K 8/06, A61K 8/37, A61K 8/92, A61K 8/97, A61K 9/107 | ||
| Abstract: | The present invention provides novel water-soluble compositions comprising sesquiterpene coumarin enriched fractions containing different ratios of sesquiterpene coumarin derived from Ferula species for the treatment of Parkinson's disease via inhibition of MAO enzyme (MAO-A and MAO-B). The invention also provides a method of preparation of ethyl-acetate extract and sesquiterpene coumarin enriched fractions from asafoetida (Hing) that is oleo-gum-resin of Ferula assa-foetida using silica gel column chromatography wherein the mobile phase consists of differing compositions of hexane, toluene, chloroform, ethyl-acetate and methanol. The invention provides the method to prepare the formulation using a multistep process comprising of preparing sesquiterpene coumarin enriched fraction followed by preparing water-soluble formulation. The final composition improves the water solubility, imparts long-term stability, exerts MAO inhibitory activity, and improves pharmaceutical compliance. The product can be formulated into liquid, semi-solid, solid and gel dosage forms for the management and treatment of Parkinson's disease through the inhibition of MAO and finds application in pharmaceutical, nutraceutical, phytochemical, and healthcare industries. |
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