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 Technology Profile

Title:

A Liposomal Composition of Photo System-I for Treatment of Cancer
Value Proposition:
  1. The invention provides a novel formulation of natural product, LDV liposomal formulation of PSI, as an anti-cancer agent.
  2. LDV liposomal formulation of PSI can be prepared easily and is easily available compared to the other marketed anti-cancer drugs.
  3. It costs very little to isolate PSI from green leaves and isolation process is very easy.
  4. The marketed cost of PSI will be very cheap compared to the known marketed anti-cancer drugs.
  5. LDV liposomal formulation of PSI should have fewer side effects.
  6. LDV liposomal formulation of PSI specifically kills the cancer cells.
  7. The main problem with the known anticancer drug is bioavailability. LDV liposomal formulation of PSI being water soluble reduces such problem.
Summary Application:

The invention provides LDV-liposomal formulation of Photosystem I(PSI) useful for anti-cancer therapy. More specifically the present invention provides LDV liposomal formulation of PSI, which specifically targets as well as kills B16F10 (mouse melanoma) and A375 (human melanoma)cancer cells without affecting the WI38 (normal lung fibroblast) cell.The PSI in the LDV liposomal formulation is isolated from Indian spinach leaves, Spinaciaoleracea.
Advantages:

The invention provides LDV-liposomal formulation of Photosystem I(PSI) useful for anti-cancer therapy.
Tech. Readiness Level:
CSIR-Indian Institute of Chemical Biology
CSIR-Indian Institute of Chemical Biology[CSIR-IICB]
:  director[at]iicb[dot]res[dot]in
:91-33-24730492
:https://iicb.res.in/
Industrial Applications: Biotechnology [Biological Science]
Patent(s): IN368113
Patent Application(s): NIL
Other IPR(s): NIL