New Invention Profile
| Publication No: | IN202311086230 [India] | Application No: | IN202311086230 |
| Title: | A method for production of bioactive withanolides from withania somnifera | ||
| Publication Date: | 04-07-2025 | File Date: | 15-12-2023 |
| Inventor(s): | Karuna Shanker; Mausam Singh; Neerja Tiwari; Ramdas; Amrat Pal Singh; Puja Khare; Kapil Dev; Rajesh Kumar Verma; Saudan Singh; Prabhodh Kumar Trivedi | ||
| IPC Classification: | A61K36/81, A61P25/00, A61P25/28, B01D11/04, C07J71/00 | ||
| Abstract: | The present invention relates to a to a new process technology for the extraction, enrichment and simultaneous production of four withanolides (withanoside-IV, withaferin-A, withanolide-A and withanone) of formulae (1) from Ashwagandha (Withania somnifera) and other plants and products therefrom. The process comprises preparation of most suitable homogeneous binary/ ternary/ quaternary/ tetra mixture of deep eutectic solvent (DES) as extractant characterized by brix degree; preparation of de-chlorophyll withanolides rich extract from dry/fresh roots/leaves/stem of cultivated/wild varieties of W. somnifera, using aforesaid DES solution by hot/ultrasonic extraction; enrichment with organic solvent probably ethyl acetate/ chloroform by trituration/liquid-liquid partitioning ; and simultaneous isolation of withanoside-IV, withaferin-A, withanolide-A and withanone of appreciable purity by flash chromatography in a single run without additional step of purification. These withanolides are having pharmacological/ therapeutic/ cosmeceutical significance with anti-Alzheimer, anti-stress, and neuroprotective and bone formation activities. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]