New Invention Profile
| Publication No: | WO2026176471 [PCT] | Application No: | PCT/IN2026/050284 |
| Title: | A mutant LC3B allosteric switch for autophagy regulation | ||
| Publication Date: | 27-08-2026 | File Date: | 18-02-2026 |
| Inventor(s): | Thukral Lipi; Gahlot Deepanshi; Jain Niyati | ||
| IPC Classification: | C07K14/47, A61K38/17, A61P35/00, C12N15/12, C12N15/63, C12N15/85 | ||
| Abstract: | The present invention relates to a mutant LC3B allosteric switch, wherein three specific residues have been mutated to either reduce or enhance receptor binding, compared to the wild- type protein. In particular, the present invention provides a method for generating conformational ensemble of lipidated protein on the membrane and introducing specific mutations within the protein activation switch that is indirectly altering protein binding pocket without disrupting its functional domains. The identification of an activation site opens avenues for the development of small molecules or peptides to enhance or regulate protein activity, providing a new dimension for therapeutic interventions. Therefore, by linking the structural insights of lipidated forms to functional outcomes, the invention advances knowledge on LC3 activity regulation, which could further be utilized to modulate the autophagy pathways. | ||
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