A Pharmaceutical Composition Useful for the Treatment of Benign Prostate Hyperplasia

The present invention is directed to pharmaceutical compositions and methods for treatment of prostate hyperplasia in a subject. The pharmaceutical composition includes a therapeutically effective amount of compound mahanine, or derivatives, or analogues, or pharmaceutically acceptable salt thereof.
The present invention is further directed to a method of isolating compound mahanine, comprising an extract obtained from the leaves or any other plant part of from Murraya koenigii. Wherein the said process comprises homogenizing the dried leaves, or any other plant part of Murraya koenigii with water, wherein the ratio used is 1:1, followed by freeze drying, followed by purification with mahanine as the pharmaceutically active fraction from the leaves.
A therapeutically effective amount of a compound mahanine obtained from an herbal extract of Murraya Koenigii, its derivative, its analogue, or a synthetically produced pharmaceutically acceptable salt of the compound mahanine, or its derivative, or its analogue in an acceptable carriers, excipient, diluent, and solvent, as a pharmaceutical composition for the treatment of prostate cancer.
The so purified molecule, mahanine has the anti-carcinogenic activity as it induces apoptosis of specifically androgen independent and androgen dependent prostate cancer cells in a time and dose dependent manner. Leaf extract caused significant apoptosis of all these cell lines (75% cell death in 96 hrs) with 200 μg/ml dosage.

A method for use of a compound mahanine in the treatment of benign prostate hyperplasia and prostate diseases.

Can be made available in wide ranging formulations pharmaceutical composition is in an oral, intravenous, intramuscular, or subcutaneous formulation for using various delivery routes
High specificity of the extract and mahanine for inducing apoptosis in prostate cancer cells
No indication of any toxicity, other cells such as hepatocytes, cardiomyocytes, and skeletal muscle are not killed by the pharmaceutical composition of this invention
The pharmaceutically active fraction can be extracted from any plant parts be it leaves, stems, fruits, or any other part of the Murraya koenigii.
Simplified method of bioactive extraction and a simplified fast and inexpensive process for the preparation of fraction mahanine possessing significantly high biological activities relevant to treatment, relief and remedy of prostate cancer
Pharmaceutical composition which is highly compatible for human consumption