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Publication No: IN202411061598 [India] Application No: IN202411061598
Title: A process for the preparation of bempedoic acid
Publication Date: 20-02-2026 File Date: 13-08-2024
Inventor(s): Dumbala Srinivasa Reddy; Remya Ramesh; Chada Raji Reddy; Satya Ravi Teja Miriyala; Adla Vijender; Rahul Choudhury
IPC Classification: A61K31/20, C07C51/09, A61P9/00, A61P3/06, C07C59/245
Abstract:
The present disclosure relates to a process for the preparation of bempedoic acid or its pharmaceutically acceptable salts. The main strategy involves preparing the keto  diacid intermediate through hydrolysis of ketene intermediate to produce bempedoic acid, thereby avoiding the use of the dialkylation of p-toluenesulfonyl methyl  isocyanide (TosMIC) reagent. The present disclosure also provided intermediates for the preparation of bempedoic acid.
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