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Publication No: IN202311073665 [India] Application No: IN202311073665
Title: A PROCESS FOR THE PREPARATION OF GLIFLOZIN AGLYCONES
Publication Date: 02-05-2025 File Date: 27-10-2023
Inventor(s): Chada Raji Reddy; Chennam Ramu; Subhash Ghosh; Gangarajula Sudhakar; Kumaraguru Thenkrishnan; Avula Shivakrishna
IPC Classification: C07H 7/04, A61K 31/7034, A61P 3/10, C07H 15/04, C07H 1/00, C07D 309/10
Abstract:
The present invention relates to a novel process for the preparation of gliflozin aglycone through a telescopic approach using ortho-lithiation of 1,4-dihalobenzene  followed by reacting with corresponding aromatic or heteroaromatic aldehydes and reduction of the resulted in diarylmethanol or (aryl)(heteroaryl)methanol  intermediate as key steps.






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