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Publication No: WO2025088634 [PCT] Application No: IN2024/052131
Title: A PROCESS FOR THE PREPARATION OF GLIFLOZIN AGLYCONES
Publication Date: 01-05-2025 File Date: 25-10-2024
Inventor(s): Sudhakar Gangarajula; Ramu Chennam; Ghosh Subhash; Reddy Chada Raji; Thenkrishnan Kumaraguru; Shivakrishna Avula
IPC Classification: C07C 15/16, C07C 25/18, C07D 307/04, C07D 333/54
Abstract:
The present invention relates to a novel process for the preparation of gliflozin aglycone through a telescopic approach using ortho-lithiation of 1,4-dihalobenzene followed by reacting with corresponding aromatic or heteroaromatic aldehydes and reduction of the resulted in diarylmethanol or (aryl)(heteroaryl)methanol intermediate as key steps.

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