New Invention Profile
| Publication No: | EP4622975 [Europe] | Application No: | EP2023894140 |
| Title: | A process for the preparation of ledipasvir | ||
| Publication Date: | 01-10-2025 | File Date: | 24-11-2023 |
| Inventor(s): | Gangarajula, Sudhakar; Chennam, Ramu; Kumaraguru, Thenkrishnan; Baburao Rode, Haridas; Maddi Reddy, Sridhar; Chada Reddy, Raji; Ghosh, Subhash | ||
| IPC Classification: | C07D047108, C07C027122, C07D040304, C07D040314 | ||
| Abstract: | The present disclosure relates to process for the preparation of Ledipasvir (I) or of its pharmaceutically acceptable salts. The present disclosure also provides novel intermediates (IV–XI) that are used in the synthesis of Ledipasvir. The main strategies of the present invention are late-stage functionalization such as difluorination and cyclopropanation of the key intermediates of Ledipasvir (I). |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]