New Invention Profile
| Publication No: | IN202211068208 [India] | Application No: | IN202211068208 |
| Title: | A process for the preparation of ledipasvir | ||
| Publication Date: | 31-05-2024 | File Date: | 25-11-2022 |
| Inventor(s): | Gangarajula Sudhakar; Chennam Ramu; Kumaraguru Thenkrishnan; Haridas Baburao Rode; Maddi Sridhar Reddy; Chada Raji Reddy; Subhash Ghosh | ||
| IPC Classification: | C07D 403/14, A61K 31/675, A61K 31/4184, A61K 31/513, A61K 31/506 | ||
| Abstract: | The present disclosure relates to process for the preparation of Ledipasvir (I) or of its pharmaceutically acceptable salts. The present disclosure also provides novel intermediates (IV?XI) that are used in the synthesis of Ledipasvir. The main strategies of the present invention are late-stage functionalization such as difluorination and cyclopropanation of the key intermediates of Ledipasvir (I). Formula (I) |
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