A Promising Therapeutic Lead from Medicinal Plant: Hope for Targeting Cancer and Cancer Stem like Cells

The present invention relates to a formulation comprising extracts of different plants( M. koenigii, C.sinesis, A. marmelos, C.tamala, S.oleracea, O tenuiflorum,)and combination thereof for management of cancer.The formulation is having growth =inhibitory activity against differnt cancer cells and cancer stem like cells.

Abundantly available across India in all seasons Lead molecule: Carbazole Alkaloid (CM-5) medicinal value reported in Charaka Samhita. Non toxic to CD34+ progenitor cell, normal blood cells and astrocytes, normal lung/kidney cell lines from human to monkey.Showed NO acute and chronic toxicity towards normal mice

Shows anti-proliferative activity against cancer cells(in vitro/ex vivo/ in vivo)

In vitor studies with CM-5,Mechanism of Apotosis induced by CM-5, Toxicity of CM-5, In vivo and ex voivo studies with CM-5 , Herbal extract enriched with CM-5