New Invention Profile
| Publication No: | IN202211070747 [India] | Application No: | 202211070747 |
| Title: | Activators of kat3b/p300 histone acetyltransferases and uses thereof | ||
| Publication Date: | 14-06-2024 | File Date: | 07-12-2022 |
| Inventor(s): | Damodara Reddy Nandarapu; Tapas Kumar Kundu; Jhajan Lal; Smitha Asoka Sahadevan | ||
| IPC Classification: | C12N 9/10, A61P 35/00, A61N 5/10, A61P 25/28, A61K 45/06 | ||
| Abstract: | The invention provides novel halogen rich salicylanilides compounds that enhancing histone acetylation. An efficient process was developed for the synthesis of novel HAT activators. The disclosed compounds increased cell permeability without conjugation to the carrier, enhanced in vitro acetyltransferase activity and activation at lower concentration in both in vitro and in vivo makes it a better small molecule activator of p300 acetyltransferase than its parent molecule TTK21. The invention further provides methods for treating neurodegenerative disorders, cancer and spinal cord injury. | ||
CSIR-Central Drug Research Institute[CSIR-CDRI]
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Industrial Applications
Biomolecules [Biological Science]
Diagnostics [Medical Devices and Diagnostics]
Synhtesis Procesess [Drugs and Pharmaceuticals]