The present invention relates to the design and development of aminopyridine analogues, which can be used as therapeutic agents for the treatment of endocrine metabolic and central nervous system disorders, and a process of preparing said novel compounds. Specifically, the present invention relates to 6-alkyl/aryl-substituted-2-aminopyridine and their analogues, processes for preparing the said compounds and to their use in the treatment of obesity, substance abuse and related neurological disorders.