New Invention Profile
| Publication No: | IN202411012562 [India] | Application No: | IN202411012562 |
| Title: | An autonomous process for selective photo-bromination and nucleophilic substitution of sartan intermediates and their analogues | ||
| Publication Date: | 12-09-2025 | File Date: | 21-02-2024 |
| Inventor(s): | Singh, Ajay Kumar; Aand, Dnyaneshwar; Rana, Abhilash | ||
| IPC Classification: | B01J001908, B01J001912, C07B004108, A61K00314184, A61K00314178, C07D025704 | ||
| Abstract: | The present invention relates to fabricating a pilot-scale solar tracker continuous flow reactor for the photochemical reaction. The present invention, particularly, relates to a pilot scale process for synthesis of formula 1, which key intermediates of various intermediate of various angiotensin II receptor blockers (ARBs). More particularly, the present invention relates to an integrated continuous flow reactor platform with Bayesian optimization (BO) assisted reaction optimization that can autonomously explore the optimal conditions for photochemical bromination reaction for the synthesis of Formula 1 and Formula 2. Moreover, autonomously explored bromination conditions are seamlessly integrated with continuous flow tools to synthesize, extract, and purify the Angiotensin II receptor blocker intermediate (formula 3). |
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: director[at]iict[dot]res[dot]in
:91-40-27193030
:https://www.iict.res.in