New Invention Profile
| Publication No: | IN202311063601 [India] | Application No: | IN202311063601 |
| Title: | AN ELECTROCHEMICAL SENSOR FOR DETECTION OF HOMOCYSTEINE USING COPPER-COUMARIN ELECTRODES | ||
| Publication Date: | 28-03-2025 | File Date: | 21-09-2023 |
| Inventor(s): | Pandiaraj Manickam; Sriraja Subhasri Paramasivam; Pabitra Baran Chatterjee; Snehasish Debnath | ||
| IPC Classification: | G01N 27/26, G01N 27/30, C07F 1/08, G01N 27/327, C07D 405/12, C07D 311/12 | ||
| Abstract: | The present invention relates to a copper coumarin compound of Formula A [C20H20CuN4O(NO3)2] electrode for electrochemical sensing of homocysteine (Hcy) in carbonate-bicarbonate buffer at pH 10.2-10.8, even in the presence of higher concentration of other competing species such as cysteine, glutathione, ascorbic acid. The copper-coumarin electrodes based electrochemical sensor can be measure Hcy selectivity in serum sample even at a low concentration (1 ?M). The copper-coumarin electrodes based electrochemical sensor is suitable for measuring Hcy in real time analysis since no requirement of binding time and the electrode modification procedure is simple. The limit of detection and limit of quantification for Hcy is 0.025 ?M and 0.077 ?M with R2 square value 0.96. The peak current observed at the peak potential showed a linear increase in current with respect to Hcy concentrations. Other biothiols such as cysteine (Cys) and glutathione (GSH) did not produce any detectable signal at the peak potential observed for Hcy, indicating the selective nature of the electrosensor towards Hcy. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Electromagnetics [Physics]
Sensors [Electronics]