The present invention discloses an improved process for the efficient solidification of biomedical waste that is capable of simultaneously treating and disinfecting solid and fluid samples. The process comprises of the addition of the waste samples to an alkaline aqueous solution followed by the addition of a solid material at a defined volumetric and/or weighted composition leading to instantaneous solidification with >99.9% microbial disinfection and an all-in-one disinfecting device 10 for treatment of biomedical waste.