New Invention Profile
| Publication No: | DE112022004799 [Germany] | Application No: | DE112022004799 |
| Title: | AN IMPROVED PROCESS FOR THE PREPARATION OF NITAZOXANIDE AND INTERMEDIATES THEREOF | ||
| Publication Date: | 14-08-2024 | File Date: | 21-09-2022 |
| Inventor(s): | Somappa, Sasidhar Balappa; Valmiki, Praveen Kumar; Durugappa, Basavaraja | ||
| IPC Classification: | C07D 027758 | ||
| Abstract: | The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. The invention explores readily available starting materials with reaction conditions that are suitable for industrial scale applications. The present invention discloses, a single vessel process to prepare 5-nitrothiazol-2-amine starting from a very basic starting material 1,1-dimethoxy-N, N-dimethylmethanamine. Overall intermediates throughout the process is free from column chromatography and the final product Nitazoxanide is purified by precipitation. All the synthesized compounds were confirmed by various spectroscopic techniques such as Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, HRMS and elemental analysis. |
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:91-471- 2515226
:https://www.niist.res.in
Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]