Batch process shows great potential in antiretroviral drug Darunavir (DRV) synthesis, but the longer process time, expensive catalyst, huge manpower, highly laborious  post-synthetic work-up, transport of one intermediate from one place to another, and need of huge storage capacity are some major limitations. Herein, we report first- ever individual continuous flow process involving 7 steps and an integrated micro-total process system for the last 4 steps of API DRV synthesis. Employing this  process, DRV could be synthesize within 41 min. of total residence time with 71% yield. The use of Raney-Ni instead of palladium on carbon renders metal the process  more affordable. Present invention describes a new synthetic approach toward automated, scalable synthesis that combines techniques in automated separation, solvent  exchange and one common solvent to continue for multi-step reaction.