New Invention Profile
| Publication No: | IN202211072533 [India] | Application No: | 202211072533 |
| Title: | An RNAi-nanoparticle conjugate and method of synthesis thereof | ||
| Publication Date: | 21-06-2024 | File Date: | 15-12-2022 |
| Inventor(s): | Rathna Venkata Naga Gundloori; Lekha Dinesh Kumar; Amarnath Ram Singam | ||
| IPC Classification: | A61P 35/00, C12N 15/113, C07K 16/28, A61K 49/00, A61K 47/68 | ||
| Abstract: | The present disclosure relates generally to pharmaceuticals. More specifically, the disclosure is directed to an RNAi nanoparticle conjugate for management of cancer comprising an active ingredient, a polysaccharide, an RNAi silencer and a coating agent. The disclosure also provides a composition comprising the conjugate and a method of synthesis of the conjugate. The conjugate is non-toxic, silences EphB4 gene, and is capable of targeted cancer therapeutics with enhanced permeation. The conjugate synergistically upregulates Wnt genes by RNAi as well as demonstrates tumor suppressive action of the active ingredient. | ||
CSIR-National Chemical Laboratory[CSIR-NCL]
: director[at]ncl[dot]res[dot]in
:91-20- 25902600, 25902028
:http://www.ncl-india.org/
: director[at]ncl[dot]res[dot]in
:91-20- 25902600, 25902028
:http://www.ncl-india.org/
Industrial Applications
Bio techniques [Analytical Techniques]
Biomolecules [Biological Science]
Biotechnology [Biological Science]
Composites [Materials]
Nanomaterials [Materials]