Anti-Leishmanial Activity Of Paromomycin Entrapped In Cationic Liposomal Formulation

Paromycin was formulated with stearyl amine (SA)-bearing phosphatidylcholine (PC) liposomes for low-dose therapy, to shorten the duration of treatment and prolong the effective life of the drug.

PC-SA and PM act synergistically tilting the immunological balance in favor of protective Th1 immune responses, thus resulting in profound antileishmanial activity and long term resistance to relapse and treatment failure.

• PC-SA-associated PM induces a prophylactic effect.

• This formulation has very good antileishmanial activity, so there is a good possibility for its commercialization

• Single shot application of liposomes
• Synergistic effect of immune activating cationic liposome and PM
• Combination therapy of PC-SA and PM induce Th1 response in host which reduces relapse of V