New Invention Profile
| Publication No: | IN202411022451 [India] | Application No: | IN202411022451 |
| Title: | Asymmetric ring opening of vinyl aziridines by carboxylic acids | ||
| Publication Date: | 17-10-2025 | File Date: | 22-03-2024 |
| Inventor(s): | Nilanjana Majumdar; Suresh Kumar; Soumen Pandit; Amit Singh Adhikari | ||
| IPC Classification: | C07D295/092, B01J31/24, C07C213/00, C07C215/30, C07D207/08, C07D211/46, C07F15/00 | ||
| Abstract: | The present invention relates to an efficient method for the construction of vinyl ß-amino alcohols via a highly regio- and enantioselective iridium-catalyzed ring- opening of racemic alkenyl aziridines with carboxylic acids has been developed. The asymmetric allylic substitution occurs under ambient conditions between an in situ generated chiral iridium complex and readily abundant carboxylic acids to provide rapid access to valuable vinyl aminoalcohol derivatives in high yields, high regioselectivity and excellent enantioselectivity using only ppm-level catalyst loading. |
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: director[at]cdri[dot]res[dot]in
:91-522-2772450
:https://www.cdri.res.in