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Publication No: EP4543880 [European Patent Office (EPO)] Application No: EP23826694
Title: BETA CARBOLINE ANALOGUES AS SELECTIVE AND BIASED KAPPA OPIOID RECEPTORS AGONISTS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS
Publication Date: 30-04-2025 File Date: 24-06-2023
Inventor(s): Batra Sanjay; Yadav Prem Narayan; Yadav Veena; Kumar Lalan; Dogra Shalini; Kumari Poonam; Kumar Ajeet; Vutla Adilakshmi
IPC Classification: C07D 471/04
Abstract:
The present invention relates selective for Kappa opioid receptor (KOR) agonist compounds, their tautomeric forms, their pharmaceutically accepted salts, or prodrugs thereof, which are useful for the treatment or prevention of various diseases in which the KOR are implicated, such as treatment of prevention of neuropathic pain, visceral pain, drug addiction, hyperalgesia, arthritic inflammation or autoimmune inflammation. The invention also relates to a process for the manufacture of said compounds and pharmaceutical compositions containing them and their use.
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