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Publication No: US20230382860 [USA] Application No: US18032732
Title: Bioactive Benzocycloheptene Analogues from Himachalenes and its Applications
Publication Date: 30-11-2023 File Date: 19-04-2023
Inventor(s): Das, Pralay; N/A, Yamini; Bharti, Richa; Ram, Shankar; Bhardwaj, Vijay Kumar; Purohit, Rituraj; Singh, Damanpreet; Anand, Prince; Padwad, Yogendra S
IPC Classification: C07D 020994,C07C 031116,C07C 031710,C07C 031714, C07D 022118, C07D 030793
Abstract:
Functionalized benzocycloheptenes are one of the most important classes of bicyclic framework that have been investigated in different areas of biological activities. The claimed invention provides preparations of benzocycloheptene analogues, inhibitors of PI3K and MK2, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I, II, III, IV, V and VI may be used as anti type 2 diabetes, antipyretic, anti-inflammatory, antiepileptic, anticancer, antiulcer, CNS-stimulant, and CNS-depressant. These benzocycloheptene derivatives are useful in treatment of PI3K and MK2 related disorders.
CSIR-Institute of Himalayan Bioresource Technology
CSIR-Institute of Himalayan Bioresource Technology[CSIR-IHBT]
:  director[at]ihbt[dot]res[dot]in
:91-1894-230411
:https://www.ihbt.res.in
Industrial Applications Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes] Synhtesis Procesess [Drugs and Pharmaceuticals]