New Invention Profile
| Publication No: | AU2022354697 [Australia] | Application No: | 2022354697 |
| Title: | Cannabinoids c- and o-glycosides possessing anti-proliferative and anti-metastatic properties and process for preparation thereof | ||
| Publication Date: | 11-04-2024 | File Date: | 27-09-2022 |
| Inventor(s): | Goswami Anindya; Ali Asif; Chakraborty Souneek; Mir Bashir Khalid; Gennedi Veeranjaneyulu; Lone Iqbal Waseem; Nalli Yedukondalu | ||
| IPC Classification: | A61P35/00, A61K31/35, A61K47/54, A61P35/04 | ||
| Abstract: | The present invention conveys a fractionation method to isolate different bioactive Phytocannabinoids by solid phase extraction using HP-20 resins and one step method to synthesize C- and O-β-D-glycoside derivatives of Cannabinoid by using a β-D-glucose donor (O-Glycosyl trichloroacetimidate donor) to obtain glycosidic derivatives. The novel C-glycosides of Cannabinoids displayed significant anti-proliferative properties against wide range of human cancer cell lines as compared to their respective parent molecules. Furthermore, the C- and O glycosides of Cannabinoids also showed anti-invasive and anti-migratory activities against metastatic cancer cells of breast and pancreatic origin. When applied in combination with DNA damaging agent (5-Fluorouracil) to colorectal cancer cells, the C- and O-glycosides of Cannabinoids potentiate DNA damaging property and thus augment apoptosis resulting in an increment in the efficacy of DNA damaging drugs. |
||
CSIR-Indian Institute of Integrative Medicine[CSIR-IIIM]
: director[at]iiim[dot]res[dot]in
:91-191-2585222
:https://iiim.res.in
: director[at]iiim[dot]res[dot]in
:91-191-2585222
:https://iiim.res.in
Industrial Applications
Applications/Use [Materials]
Biological Science Processes/Methods [Biological Science]
Diagnostics [Medical Devices and Diagnostics]
Synhtesis Procesess [Drugs and Pharmaceuticals]