New Invention Profile
| Publication No: | EP4408538 [European Patent Office (EPO)] | Application No: | EP2022875338 |
| Title: | Cannabinoids C- and O-glycosides possessing anti-proliferative and anti-metastatic properties and process for preparation thereof | ||
| Publication Date: | 07-08-2024 | File Date: | 27-09-2022 |
| Inventor(s): | Goswami, Anindya; Ali, Asif; Chakraborty, Souneek; Mir, Bashir Khalid; Gennedi, Veeranjaneyulu; Lone, Iqbal Waseem; Nalli, Yedukondalu | ||
| IPC Classification: | A61P 003500, A61K 003135, A61K 004754, A61P 003504 | ||
| Abstract: | The present invention conveys a fractionation method to isolate different bioactive Phytocannabinoids by solid phase extraction using HP-20 resins and one step method to synthesize C- and O-β-D-glycoside derivatives of Cannabinoid by using a β-D-glucose donor (O-Glycosyl trichloroacetimidate donor) to obtain glycosidic derivatives. The novel C-glycosides of Cannabinoids displayed significant anti-proliferative properties against wide range of human cancer cell lines as compared to their respective parent molecules. Furthermore, the C- and O glycosides of Cannabinoids also showed anti-invasive and anti-migratory activities against metastatic cancer cells of breast and pancreatic origin. When applied in combination with DNA damaging agent (5-Fluorouracil) to colorectal cancer cells, the C- and O-glycosides of Cannabinoids potentiate DNA damaging property and thus augment apoptosis resulting in an increment in the efficacy of DNA damaging drugs. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]