New Invention Profile
| Publication No: | IL311695 [Israel] | Application No: | IL311695 |
| Title: | Cannabinoids C- and O- glycosides possessing anti-proliferative and anti-metastatic properties and process for preparation thereof | ||
| Publication Date: | 01-05-2024 | File Date: | 25-03-2024 |
| Inventor(s): | Ali Asif; Chakraborty Souneek; Gennedi Veeranjaneyulu; Goswami Anindya; Lone Iqbal Waseem; Mir Bashir Khalid; Nalli Yedukondalu | ||
| IPC Classification: | A61K 31/00, A61K 31/513, A61K 31/7048, A61K 47/54, A61P 35/00, A61P 35/04, C07H 17/04 | ||
| Abstract: | The present invention conveys a fractionation method to isolate different bioactive Phytocannabinoids by solid phase extraction using HP-20 resins and one step method to synthesize C- and O-β-D-glycoside derivatives of Cannabinoid by using a β-D-glucose donor (O-Glycosyl trichloroacetimidate donor) to obtain glycosidic derivatives. The novel C-glycosides of Cannabinoids displayed significant anti-proliferative properties against wide range of human cancer cell lines as compared to their respective parent molecules. Furthermore, the C- and O glycosides of Cannabinoids also showed anti-invasive and anti-migratory activities against metastatic cancer cells of breast and pancreatic origin. When applied in combination with DNA damaging agent (5-Fluorouracil) to colorectal cancer cells, the C- and O-glycosides of Cannabinoids potentiate DNA damaging property and thus augment apoptosis resulting in an increment in the efficacy of DNA damaging drugs. |
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