New Invention Profile
| Publication No: | IN202211059359 [India] | Application No: | 202211059359 |
| Title: | Casein manganese nanoparticle and its process of preperation thereof | ||
| Publication Date: | 19-04-2024 | File Date: | 17-10-2022 |
| Inventor(s): | Shagufta Haque; Chitta Ranjan Patra | ||
| IPC Classification: | A61P35/00, A61P17/02, G01N33/50, C12N5/071, A61K9/51 | ||
| Abstract: | The invention relates to a new fabricated casein manganese nanoparticle (CM NPs) prepared by using casein as a template for formation of nanoparticles. The present invention is simple, fast, clean, efficient and economically cheap approach. The CM NPs exhibit an escalated angiogenic activity in vitro towards different endothelial as well as in vivo through CAM and chick aorta assay. The angiogenic CM NPs show wound healing property through in vitro assays towards keratinocyte cells and in vivo experiments in mouse model. Detailed mechanism studies show that the CM NPs could enhance endothelial cell proliferation through multi- regulatory pathway mainly by ROS generation and propagating nitric oxide mediated pathway. The present invention presents a simple approach to prepare casein-based biocompatible manganese nanoparticles having multiple applications and great potential in angiogenesis for future times. | ||
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Industrial Applications
Biotechnology [Biological Science]
Diagnostics [Medical Devices and Diagnostics]
Nanomaterials [Materials]
Process [Environmental (Clean Tech)]