New Invention Profile
| Publication No: | IN202241038333 [India] | Application No: | 202241038333 |
| Title: | Cationic lipid based composition, formulation and use for nucleic acid vaccine delivery and preparation thereof | ||
| Publication Date: | 05-01-2024 | File Date: | 04-07-2022 |
| Inventor(s): | Mahadik, Namita Santosh; Bhattacharyya, Tithi; Rathore, Bhowmira; Potdar, Pooja; Immanuel, Christiana; Chilaka, Sabarinadh; Andugulapati, Sai Balaji; Sistla, Ramakrishna; Banerjee, Rajkumar; Murthy, Ella Krishna; Rao, Yogeswara D | ||
| IPC Classification: | A61, C12 | ||
| Abstract: | The present invention discloses a cationic lipid-based formulation for in vivo delivery of nucleic acid. The present invention describes the development of a lipid system that can induce efficient non-viral delivery of nucleic acid, especially RNA, for the purpose of efficient nucleic acid transfection toward eliciting vaccination in vivo. Present invention provides a lipid/RNA complex (lipoplex) formulation having sufficiently long shelf life that performs without any compromise in its transfection output. The present invention further provides cationic lipid-based formulations for RNA delivery with maximum nucleic acid complexation ability and with comparatively lesser amount of cationic lipid having higher stability. | ||
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Drug delivery [Drugs and Pharmaceuticals]
Synhtesis Procesess [Drugs and Pharmaceuticals]