CSIR Technology Portal
CSIR Technology Portal

 Technology Profile

Title:

Chebulinic Acid and its Enriched Fraction from the Fruits of Terminalia Chebula for Treatment of Benign Prostatic Hyperplasia (BPH) and its Preparation thereof

Value Proposition:
  • A plant-based therapeutic approach using Chebulinic acid and its enriched fraction from Terminalia chebula for the management and treatment of benign prostatic hyperplasia (BPH), offering an alternative to existing drug therapies.
  • Enables development of a standardized, effective, and potentially safer and more affordable solution for BPH symptom management, supported by preclinical evidence.
Summary Application:
  • A standardized Chebulinic-acid enriched fraction derived from Terminalia chebula fruits is disclosed for the prevention and treatment of benign prostatic hyperplasia (BPH) and associated symptoms.
  • Cost-effective and scalable processes are described for isolating Chebulinic acid and Ellagic acid without the use of complex chromatographic methods.
  • Formulations of the enriched fraction demonstrate therapeutic efficacy in preclinical BPH models, supporting their potential in prostate health management.
Advantages:
  • Offers a plant-derived, potentially safer and cost-effective alternative to conventional BPH therapies, with reduced reliance on synthetic drugs.
  • Uses a scalable, non-chromatographic extraction process, enabling easier translation to commercial manufacturing and improved affordability.
Commercialization Status: Licensed awaiting commercialisation
Tech. Readiness Level:
CSIR-Central Drug Research Institute
CSIR-Central Drug Research Institute[CSIR-CDRI]
:  director[at]cdri[dot]res[dot]in
:91-522-2772450
:https://www.cdri.res.in
Industrial Applications: Formulations [Drugs and Pharmaceuticals] Synhtesis Procesess [Drugs and Pharmaceuticals]
Patent Application(s): EP4210721, WO2022054100, US20230355695