New Invention Profile
| Publication No: | AU2023380432 [Australia] | Application No: | AU2023380432 |
| Title: | COMPOSITION FOR TREATING PACLITAXEL-RESISTANT BREAST CANCER AND METHOD FOR PREPARATION THEREOF | ||
| Publication Date: | 29-05-2025 | File Date: | 17-11-2023 |
| Inventor(s): | Ahmed Qazi Naveed; Anand Loveleena Kaur; Chashoo Gousia; Dogra Ashish; Fatim Kaneez; Hamza Baseerat; Khan Sameer Ullah; Khan Shahnawaz; Kumar Amit; Kumar Atul; Malik Fayaz; Maqbool Mir Shahid; Mir Sameer Ahmad; Nandi Utpal; Nazir Nadiem; Padala Anil; Paddar Masroor Ahmad; Shah Bhahwal Ali; Singh Gurdarshan; Yadav Govind | ||
| IPC Classification: | A61K 47/20, A61K 47/14, A61K 31/337, A61K 31/4174 | ||
| Abstract: | The compound IIIM-152 and its derivatives have been reported as potent stem cell modulators by down-regulating beta-catenin signalling. TNBCs are highly aggressive cancers and chemotherapy remains one of the primary treatment options. However, CSCs remains non-responsive to the Paclitaxel treatment leads to disease recurrence and metastasis and is one of the major clinical challenges. The Combinatorial treatment of IIIM eliminates the Paclitaxel Resistant Cancer Stem Cells, whereas Paclitaxel only treatment is unable to target CSCs subpopulation. Similarly, a combination of Paclitaxel-IIIM152, showed significant reduction in tumor burden and decrease in number of CSCs in excised tumours. The combination of IIIM-152 and Paclitaxel proves to be clinically efficacious in treating the Paclitaxel non-responsive highly aggressive residual cancer stem cells to achieve long lasting treatment. The invention also provides a method for preparing the composition comprising Paclitaxel and IIIM-152. |
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CSIR-Indian Institute of Integrative Medicine[CSIR-IIIM]
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: director[at]iiim[dot]res[dot]in
:91-191-2585222
:https://iiim.res.in