New Invention Profile
| Publication No: | CN120475967 [China] | Application No: | CN202480005215 |
| Title: | Composition for treating parkinson's disease | ||
| Publication Date: | 12-08-2025 | File Date: | 14-05-2024 |
| Inventor(s): | Kumar, Deepak; Chakraborty, Joy; Yatham, Priyanka; Banerjee, Chayan; Sarma, Shreya Sen | ||
| IPC Classification: | A61K31/37, A61K8/06, A61K47/14, A61K47/44 | ||
| Abstract: | The present invention provides novel water-soluble compositions comprising sesquiterpene coumarin enriched components for the treatment of parkinson's disease by inhibition of MAO enzymes (MAO-up>A and MAO-B). These sesquiterpene coumarin-enriched fractions contain different proportions of sesquiterpene coumarins derived from ferula. The invention also provides a method for preparing the ethyl acetate extract and the sesquiterpene coumarin enriched component from the resina ferulae (Hing), namely the oleoresin of the aeda salsa by using a silica gel column chromatography, wherein the mobile phase in the chromatography consists of hexane, toluene, chloroform, ethyl acetate and methanol with different proportions. The present invention provides a method for preparing a formulation using a multi-step process comprising preparing a sesquiterpene coumarin enriched component and then preparing a water soluble formulation. The final composition has improved water solubility, long-term stability, MAO inhibition activity and improved drug compliance. |
||
CSIR-Indian Institute of Chemical Biology[CSIR-IICB]
: director[at]iicb[dot]res[dot]in
:91-33-24730492
:https://iicb.res.in/
: director[at]iicb[dot]res[dot]in
:91-33-24730492
:https://iicb.res.in/
Industrial Applications
Medicinal and Aromatics Plants [Agriculture]
Post Harvest [Agriculture]
Synhtesis Procesess [Drugs and Pharmaceuticals]