New Invention Profile
| Publication No: | IN202411016683 [India] | Application No: | IN202411016683 |
| Title: | Dihydrobenzo[b,e]pyrroloazepines hybrids and a process for the preparation thereof | ||
| Publication Date: | 19-09-2025 | File Date: | 07-03-2024 |
| Inventor(s): | Indubhusan Deb; Shantonu Roy; Koushik Naskar; Imtiaj Mondal | ||
| IPC Classification: | A61K31/5517, C07D243/06, C07D487/04, C07D243/12, C07D223/16, A61K31/551, A61P35/00 | ||
| Abstract: | The current invention provides a novel electrochemical synthetic method for producing a novel dihydrobenzo[b,e] pyrroloazepines hybrides containing maleimide and tetrahydroquinoline heterocycles using specially designed olefin known as 2-amino substituted benzylidene derivatives as starting material. Seven-membered N- containing heterocycles, in particular 1-benzazepines are the integral structure of many bioactive compounds such as antidepressant drugs, anti-convulsants, anti-HIV etc. This present method provides an oxidant-free and metal-free process for the synthesis of a new class of Dihydrobenzo[b,e] pyrroloazepines hybrid containing maleimide/succinamide, benzoazepine and tetrahydroisoquinoline as well as other cyclic/acyclic amines via electrochemical C(sp3)-H functionalizing followed by cascade cyclization using easily available reagents. unique, efficient, eco-friendly, cost-effective, and safe technology has been developed to expedite the novel synthetic process. This method comprises the simple electrochemical synthesis of dihydrobenzo[b,e] pyrroloazepines derivatives using a suitable electrode and electrolyte under ambient temperature. The synthesis employs an environmentally friendly electrochemical method that doesn't require transition metals and external oxidants. This method is highly effective and scalable, contributing to both atom and step economy in the process. As a result, this methodology holds substantial significance. It presents a novel avenue for synthesizing new scaffolds that are useful as potential bioactive heterocyclic scaffolds photophysically relevant, including and chemo sensors to detect picric acid and other nitro compounds. |
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