Dihydrofolate Formulation for Dietary Supplementation as an Effective Nutraceutical Supplement and Method of Preparation Thereof

Anaemia due to dihydrofolate deficiency is highly prevalent in India, with folate deficiency being a significant contributing factor. Reports indicate that over 50% of individuals in lowincome groups suffer from folate deficiency in India. Unlike synthetic folic acid, dihydrofolate can be readily absorbed and utilized by the body, making it an effective molecule for the amelioration of anaemia.

Unmetabolized synthetic folate has been reported in the serum of individuals in developed nations where mandatory folate fortification is implemented. Consequently, there is a shift towards using biological folate derivatives for fortification. In response to this trend, we have developed methods to produce dihydrofolate tablets and capsules with enhanced stability.

Currently dihydrofolate based products are not available in the market.