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Publication No: US2024116863 [USA] Application No: US17932386
Title: Diphenyl thiourea and diphenyl urea derivatives as inhibitors of endocytosis
Publication Date: 11-04-2024 File Date: 15-09-2022
Inventor(s): Kumar Nirmal; Banerjee Indranil; Taily Irshad Maajid; Banerjee Prabal; Singh Charandeep; Sharma Anshul; Ringe Rajesh P; Thakur Krishan Gopal; Singh Priyanka
IPC Classification: C07C335/12, C07C275/30
Abstract: The present invention relates to method of inhibition of cellular endocytosis by treating the cells with compound of formula-1 Diphenylthio urea and Diphenylurea derivatives. Said invention also discloses method of treatment of infectious diseases, neurological disease, cancer, kidney disease in a subject in need thereof by administering therapeutically effective concentration of compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives which are effective inhibitors of cellular endocytosis. Said invention also discloses compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives and pharmaceutical composition comprising compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives along with suitable excipients.
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Industrial Applications Diagnostics [Medical Devices and Diagnostics] NCE [Drugs and Pharmaceuticals]