New Invention Profile
| Publication No: | IN202211044094 [India] | Application No: | 202211044094 |
| Title: | Electrospun, antibacterial metal-ion incorporated poly (Isocyanurate- urea) fibrous aerogel composites and a process for the preparation thereof | ||
| Publication Date: | 02-02-2024 | File Date: | 01-08-2022 |
| Inventor(s): | Chandrasekaran Naveen; Singaram Vengatesan; Pattanayak Deepak Kumar; Kundu Subrata; Murugavel Kathiresan; Selvaraj Seethalakshmi; Nagarajan Mohanapriya; Sam Sankar Selvasundarasekar | ||
| IPC Classification: | A61L27/18, A61L27/50, A61L27/54, D04H1/728, D01D5/00 | ||
| Abstract: | Metallic components are used as permanent fixation implants (hip, knees, spine, etc.) for human body parts, which endure until our life. Despite the enormous advantages of high mechanical strength and modulus that the metal components possess, they impose heavy-weight, corrosion and metal ion leaching issues. Moreover, fibrous ligaments / cartilages restoration will be difficult using the metallic implants. In this scenario, polymer- based materials would be more advantageous, since the polymers are light-weight and can have the mechanical flexibility in the range of elastic to tough behavior. Moreover, bio-degradable polymers can be used as temporary implants, where the polymer degrades or disintegrates with time while at the same time regenerating the damaged / diseased body part simultaneously. Since the bacterial infection is quite possible during surgical events in tissue restoration, it would be more beneficial if the scaffold can hold antibacterial properties also. Hence, the main objective of the proposed invention is to develop fibrous polymer / polymer composite materials with antibacterial properties (Ag-doped polymer systems), especially useful in making cartilage / ligaments. The metal-ion doped electrospun fibrous material is extensively characterized for structural, morphological, mechanical and physico-chemical properties. Also, the antibacterial studies are performed in simulated biological environment using Staphylococos Aureus, Escherichia Coli bacteria and the results revealed moderate to high antibacterial efficacy of the metal-ion doped polymeric fibrous materials. | ||
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