New Invention Profile
| Publication No: | IN202311014137 [India] | Application No: | IN202311014137 |
| Title: | GLUCOCORTICOID RECEPTOR-TARGETED FORMULATIONS FOR THE TREATMENT OF COLORECTAL CANCER AND PREPARATION THEREOF | ||
| Publication Date: | 06-09-2024 | File Date: | 02-03-2023 |
| Inventor(s): | Namita Santosh Mahadik; Tithi Bhattacharyya; Debabrata; Rajkumar Banerjee | ||
| IPC Classification: | A61P 35/00, A61K 9/127, A61K 31/513, A61K 31/573, A61K 31/4745 | ||
| Abstract: | The present invention provides an anti-cancer lipid-based composition that kills very aggressive colorectal cancer cells. This composition is a concoction of an anti- cancer agent, 5-Fluorouracil and a glucocorticoid receptor (GR)-targeting cationic lipid delivery system, D1X. The uptake studies of these formulations have showed that formulations with dexamethasone enter into nucleus, bind GRE region and upregulate CYP3a5 gene. The intensity of upregulation is better than liposome without dexamethasone. Same results found in in vivo studies, the D1X5-FU shows better tumor regression and survivability than FOLFOX and FOLFIRI. The biodistribution studies showed that D1X5-FU targets only tumor tissues, not other organs. The pilot studies of tumor regression by other liposomal formulations- D1XLeucovorin, and D1XOxaliplatin has showed better tumor regression than FOLFOX and FOLFIRI. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Formulations [Drugs and Pharmaceuticals]
Synhtesis Procesess [Drugs and Pharmaceuticals]