Glycolipid Based Niosomal Delivery System for Drugs and Biomolecules

Efficient and safer delivery of drugs (with low solubility and poor bioavailability) and is a challenging task in pharmaceutical and biotechnological industries.

Niosomes, by virtue of its vesicular structure, can house both hydrophilic and hydrophobic molecules within its compartments. By exploring the structure-forming attributes of acidic sophorolipid (a microbial glycolipid) we have developed a carrier system for drug and biomolecule delivery. The versatile system can be synthesized with different charges (+Ve/-Ve), size and physical characteristics. 

They are highly suitable for the delivery of drugs having poor bioavailability due to low water solubility. A prototype of the system has been tested for the delivery of poorly soluble drug amphotericin B. This preparation can also be used for gene and protein delivery and for bio-imaging purposes.