Improved synthetic process for the synthesis of 2-(4-chlorophenyl)-2-hydroxy-N-(3-methoxy-4-(prop-2-yn-1-yloxy)phenethyl)acetamide, a key intermediate for the synthesis of Mandipropamid.

Fungicide Mandipropamid is the class of mandelic acid amides and a fungicide from the family of CAA fungicides (carboxamides). Mandipropamid is an inhibitor of cellulose synthase and is effective against downy mildew and Phytophthora infestans. Mandipropamid is a very effective active Ingredient: the EC 80 against Phythophthora infestans is 0.1 mg−1, that against Plasmopara viticola is 1.2 mg −1.

●None of the toxic Cyanide sources like HCN, KCN and the expensive Pd or Bromine sources were employed in this synthetic process.

● The amide coupling was achieved using a relatively easily accessible coupling reagent at room temperature to deliver an intermediate for mandipropamid.

●In our quest to enhance the efficiency and practicality of this reaction, we've uncovered avaluable process; this newly devised process offers a straightforward and achievable alternative, boasting advantages such as low cost, high yield, and suitability for large-scale industrial production.

• The process provides a mild, short (Four-step), hazardous, reagent-free strategy for synthesizing the key intermediate from Vanillin for Mandipropamid.
• Competing technology is not available at present, and Pharma and the fine chemical industry can employ this cost-effective IICB- process for tilorone, an antiviral drug.