Improved synthetic process for the synthesis of 2-(4-chlorophenyl)-2-hydroxy-N-(3 methoxy-4-(prop-2-yn-1-yloxy)phenethyl)acetamide, a key intermediate for the synthesis of Mandipropamid.

In our quest to enhance the efficiency and practicality of this reaction, we've uncovered a valuable process; this newly devised process offers a straightforward and achievable alternative, boasting advantages such as low cost, high yield, and suitability for large-scale industrial production.

• Mandipropamid is the class of mandelic Mandipropamid Category acid amides and a fungicide : Fungicide from the family of CAA fungicides (carboxamides).
• Mandipropamid is an inhibitor of cellulose synthase and is effective against downy mildew and Phytophthora infestans.
• Mandipropamid is a very effective active ingredient: the EC 80 against Phythophthora infestans is 0.1 mg l −1, that against Plasmopara viticola is 1.2 mg l −1

• None of the toxic Cyanide sources like HCN, KCN and the expensive Pd or Bromine sources were employed in this synthetic process.
• The amide coupling was achieved using a relatively easily accessible coupling reagent at room temperature to deliver an intermediate for mandipropamid