New Invention Profile
| Publication No: | IN202311028946 [India] | Application No: | IN202311028946 |
| Title: | LIPOSOMAL FORMULATION FOR TREATMENT OF VISCERAL LEISHMANIASIS | ||
| Publication Date: | 25-10-2024 | File Date: | 20-04-2023 |
| Inventor(s): | NAHID ALI; NICKY DIDWANIA; MOHD KAMRAN; ABDUS SABUR; SARFARAZ AHMAD EJAZI | ||
| IPC Classification: | A61K 39/00, G01N 33/569, A61P 33/02, C07K 14/44, G01N 33/68 | ||
| Abstract: | Antigens from multiple sources is a promising strategy to effectively stimulate all immuno-phenotypic sections of a diverse population. Therefore, combination of multiple protective antigens is a rationale strategy to boost immunogenicity of the vaccine designed for immunization in heterogeneous population as well as to use in effective diagnosis in all endemic areas. The strategy to combine antigens isisis to construct a fusion chimeric multivalent antigen. The present invention relates to the diagnostic and vaccine potential of a recombinant multiantigenic T cell epitope enriched fusion protein comprising of three Leishmania donovani proteins, glycoprotein 63 (GP63), elongation factor 1 a (EF1-a) and cysteine protease C (CPC) against visceral leishmaniasis. The said invention in particular relates to designing, cloning and purification of a novel T cell enriched multiantigenic recombinant protein for detection of Leishmania infection in the form of antigen-specific antibodies in the biological samples such as serum and urine. Additionally the said fusion protein is used to the protective efficacy of the antigen in BALB/c mice against experimental visceral leishmaniasis. | ||
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