New Invention Profile
| Publication No: | IN202311018884 [India] | Application No: | IN202311018884 |
| Title: | NON-INVASIVE DETECTION OF TBI USING GAN HEMT BASED HANDHELD SYSTEM | ||
| Publication Date: | 20-09-2024 | File Date: | 16-03-2023 |
| Inventor(s): | Rajiv Ranjan Thakur;Anil Kumar Saini;Rajeev Taliyan;Nidhi Chaturvedi | ||
| IPC Classification: | G01N 33/543, A61B 5/00 | ||
| Abstract: | Traumatic Brain Injury (TBI) is an injury to the brain from external forces such as road traffic accident, sports injury, warfare, etc., leading to morbidity and mortality among the people of various age groups. Currently, Glasgow Coma Scale (GCS) is in use to classify the TBI into mild, moderate, and severe. CT or MRI Scan are used for its diagnostics which are expensive, involve exposure to ionizing radiations, and their availability is a concern in every location, thus limiting the screening frequency. Colorimetric Techniques such as Enzyme-Linked Immunoassay (ELISA) can also be used but is time-consuming. The early identification of TBI using its biomarkers could help clinicians prevent or at least reduce the extent of potential damage at an early stage, which is crucial as it may lead to chronic problems. This raises a need for the development of a hand-held system for real-time non-invasive detection of TBI. The system will also help clinicians in early medical diagnosis, management, and decision-making for CT or MRI, which has been reported to cut down the need for CT scans by up to 40%. The diagnostics use of salivary biomarkers poses advantage in terms of its simplicity in collecting specimens, opening an avenue for self- collection at home by the patient leading to reduced healthcare costs. The system detects TBI biomarkers present in saliva in a very small amount of pg/ml using specific conjugation of the antibody and target analyte over the bio-functionalized chips. The developed system is easy to handle, ultra-sensitive with excellent response time of less than 5s. |
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| Startup Options: | Advantage: 1. Non-invasive detection of TBI biomarkers using saliva. 2. The detection platform is the handheld system using GaN HEMT biosensor. 3. GaN HEMT based biosensors and systems are used for the detection of UCH-L1, GFAP, IFN-?, Aß, IL-6. 4. Compact, easy to handle, and ultra-sensitive system for detection of TBI with response time of less than 5s. 5. The developed system is able to detect the targeted TBI biomarker or protein antigen in the range of pg/ml with a better resolution in the drain current. 6. Surface functionalization and antibody immobilization process for enhanced sensitivity. |
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Industrial Applications
Diagnostics [Medical Devices and Diagnostics]
Electromagnetics [Physics]
Radiology [Medical Devices and Diagnostics]