New Invention Profile
| Publication No: | IN202311015549 [India] | Application No: | IN202311015549 |
| Title: | PALMITOYL-THIAZOLIDINE CARBOXYLIC ACID DERIVED DIPEPTIDES AS VACCINE ADJUVANTS AND THE PROCESS FOR PREPARATION THEREOF | ||
| Publication Date: | 13-09-2024 | File Date: | 07-03-2023 |
| Inventor(s): | Halmuthur Mahabalarao Sampath Kumar; Talati Mamta Natvarlal; Vemireddy Sravanthi | ||
| IPC Classification: | A61P 35/00, A61K 39/39, A61P 29/00, A61K 39/00, C07F 9/38 | ||
| Abstract: | Toll-like receptor2 (TLR2) is known to detect a wide variety of PAMPs from a large diversity of pathogens due to its capability to identify ligands as a heterodimer with either TLR1 or TLR6. TLR family represents a highly attractive target for the development of novel immunomodulators to treat infections, inflammatory diseases, and cancer treatments. Herein, thiazolidine analogues of Pam3CSK4 encompassing different L-amino acid residues at the C-terminus of the peptide moiety are designed with a view to evaluate their possible TLR2 agonistic activity. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]