New Invention Profile
| Publication No: | EP4496800 [European Patent Office (EPO)] | Application No: | EP2023774172 |
| Title: | PEPTIDE TO TREAT ALPHA-SYNUCLEIN AMYLOID BASED DISORDERS | ||
| Publication Date: | 29-01-2025 | File Date: | 21-03-2023 |
| Inventor(s): | Sharma, Deepak Kumar; Gupta, Arpit; Raghava, Gajendra Pal Singh; Gautam, Ankur; Koul, Anil; Singh, Priyanka | ||
| IPC Classification: | C07K 000700, A61P 002528 | ||
| Abstract: | The present invention relates to a cell-penetrating peptide and its derivatives to inhibit α-synuclein fibrillation. The present invention specifically relates to a peptide-based inhibitor of Parkinson's Disease. The present invention discloses the identification of the peptides permeable to blood brain barrier for inhibition. α-synuclein fibril formation is observed in the presence of peptides as indicated by SEQ. ID-7, SEQ. ID-8 wherein the SEQ. ID-7, SEQ. ID-8 are truncated versions of SEQ. ID-4 having the homology of 83% and 75% respectively. It provides a peptide having an amino acid sequence of Formula 1. The present invention also provides a pharmaceutical composition comprising a peptide of Formula 1 along with the pharmaceutically acceptable excipient(s) having inhibitory activity against ß-sheet polymerisation of amyloidogenic proteins. The analysis showed that peptides corresponding to SEQ. ID-7, SEQ. ID-8 are better inhibitors than SEQ. ID-4 against α-synuclein fibrillation. |
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