Pharmaceutical Formulations for Management of Cancers

1. Preparation time is short (~4 days) with high yield of biologically active fraction
2. Stability of raw material is very high, at 4-25^oC for ~4 years. Final product is at 4-25^oC for 2-4 years
3. This extract showed growth inhibition effect at very low dose (IC50: 5-20 µg/ml)
4. Showed good ex vivo effect against primary cells isolated from tissues, blood, ascites from cancer patients
5. Exhibiting its biological activity against drug-resistant cell lines.
6. Minimum toxic effects on normal cells/tissues/ serum
7. Maximum tolerated dose is very high, ~3000mg/kg/day
8. Combination therapy with extract/fraction reduced dose of highly toxic clinically approved anti-cancer drugs.
9. It can be administered through oral (tablet/capsule)/intra-peritoneal/sub cutaneous/suspension etc.

The invention relates to a formulation containing organic compounds useful for management of cancers and the process of preparation thereof, wherein the  extract/fraction consist of a few biologically active carbazole alkaloids from Murraya koenigii leaves or any other part of plant. The invention exhibits the anticancer effect in many different cancer cell lines with various mutations through apoptosis, detachment-induced cell death (Anoikis) and autophagy at low dose within short time and is also useful for the management of tumour metastasis. The invention also shows very good activity against primary cells with high percent of stem cells isolated from drug resistant and drug sensitive cancer patients.

Anti Cancer drug can be administered through oral (tablet/capsule)/intra-peritoneal/sub cutaneous/suspension etc