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 Technology Profile

Title:

Poly-Beta-Amino-Ester Polymer Nanocomplex as a Carrier Molecule for Crossing Blood Brain Barrier
Value Proposition:

The technology provides a non-viral delivery platform addressing one of the most significant bottlenecks in CNS drug development, the efficient transport of nucleic acid therapeutics across the Blood-Brain Barrier. Key value delivered to industry:

  • Efficient BBB Penetration - Nanocomplexes designed for transcytosis across BBB endothelial cells
  • Safer Gene Delivery Platform - Biodegradable polymer carriers reduce safety concerns associated with viral vectors
  • Versatile Therapeutic Platform – Can be fine tuned to deliver multiple nucleic acid therapeutics including DNA, mRNA, siRNA, CRISPR gene editing systems
  • Scalable Manufacturing - Polymer synthesis processes allow flexible and scalable production
  • Platform Technology - The technology can support multiple therapeutic programs, making it valuable for pharmaceutical and biotechnology companies
Summary Application:

Therapeutic Applications

  • Neurodegenerative diseases
  • Brain cancer
  • Rare genetic neurological disorders

Gene Therapy Applications

  • Gene replacement therapies
  • mRNA therapeutics
  • siRNA delivery
  • CRISPR based genome therapeutics

Platform Applications

  • CNS drug delivery
  • Next-generation nucleic acid therapeutics
  • Precision medicine

Research Applications

  • Neuroscience and CNS research
  • Functional genomics
  • Neuroscience research
Advantages:

 

Feature

Existing Systems

Proposed Technology

Delivery platform

Viral vectors / lipid nanoparticles

Biodegradable polymer nanocomplex

Safety

Immunogenicity risk

Non-viral and biocompatible

BBB penetration

Limited

Designed for BBB transcytosis

Cellular uptake

Non-specific uptake mechanisms

Distinct and controlled BBB transport mechanisms

Particle size

Larger nanoparticles

Nanocomplex

Manufacturing

Complex

Scalable polymer chemistry

Administration

Often invasive/local delivery

Potential systemic delivery

Cargo versatility

Limited

DNA, mRNA, siRNA, CRISPR

Storage

Variable stability

Stable nucleic acid nanocomplexes
Tech. Readiness Level:
CSIR-Institute of Genomics & Integrative Biology
CSIR-Institute of Genomics & Integrative Biology[CSIR-IGIB]
:  director[at]igib[dot]res[dot]in
:91-011-27662407
:https://www.igib.res.in
Industrial Applications: Biochemicals [Biological Science] Biotechnology [Biological Science] Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Patent Application(s): IN202511080651